January 1, 2006Clinical and Experimental Hypertension
Comparison of Simultaneous Measurements of Blood Pressure by Tail-Cuff and Carotid Arterial Methods in Conscious Spontaneously Hypertensive and Wistar-Kyoto Rats
Why the study?
Does tail-cuff blood pressure measurement accurately reflect direct intra-arterial blood pressure in conscious WKY and SHR rats?
Population
Conscious, restrained Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)
Comparison
Tail-cuff blood pressure (TCBP) measurement vs Direct intra-arterial carotid artery blood…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Tail-cuff overestimates Ang II BP rises in SHR despite correlation with direct measures; leaves open its reliability for interventional rodent studies.
Structured PICO
Does tail-cuff blood pressure measurement accurately reflect direct intra-arterial blood pressure in conscious WKY and SHR rats?
P
Population
Conscious, restrained Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)
I
Intervention
Tail-cuff blood pressure (TCBP) measurement
C
Comparator
Direct intra-arterial carotid artery blood pressure (CABP) measurement
O
Outcome
Validity and correlation of systolic blood pressure (SBP) measured by TCBP compared to direct intra-arterial measurementssurrogate
While tail-cuff blood pressure correlates with direct arterial measurement in conscious rats, its wide limits of agreement and poor reproducibility suggest caution in its use, particularly for detecting specific drug-induced pressure changes.
Cite This Study
Ibrahim et al. (2006) studied this question.