Isolated precordial T-wave inversion may serve as an early electrocardiographic sign of impending acute anterior wall myocardial infarction.
May warrant vigilance for anterior MI in ischemic settings; leaves open validation beyond case reports.
T-wave inversion, in leads localized to a small segment of the precordium, has in rare instances been described as a normal variant. The present report concerns a number of individuals in whom more or less similar T-wave changes developed under circumstances suggesting myocardial ischemia, and who went on to develop acute infarction of the anterior wall of the heart. This may be a clinical analogue of the brief T-wave inversion which has been observed early in experimental coronary artery compression.
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Schlant et al. (1954) studied this question.
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