Key result
Thick filament mechano-sensing acts as a common force-feedback mechanism in skeletal and cardiac muscles, adapting the number of active myosin motors and energetic cost of contraction to the load.
Population
Skeletal and cardiac muscles
Design
Review
Authors
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No immediate clinical impact; extends thick filament mechano-sensing from skeletal to cardiac muscle.
Thick filament mechano-sensing provides a common mechanism in striated muscle to adapt the energetic cost of contraction to the load, offering new insights into the Frank-Starling law and hypertrophic cardiomyopathy.
Piazzesi et al. (2018) conducted a review in Striated muscle physiology. Thick filament mechano-sensing was evaluated. Thick filament mechano-sensing acts as a common force-feedback mechanism in skeletal and cardiac muscles, adapting the number of active myosin motors and energetic cost of contraction to the load.
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