Key result
Thick filament stress directly controls the orientation of myosin motors and the activation of thick filaments independently of intracellular calcium concentration.
Population
demembranated muscle fibres
Design
Preclinical
Authors
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Does not yet alter clinical muscle management; leaves open whether thick filament stress regulates human myosin activation independently of calcium.
Thick filament mechano-sensing directly controls myosin motors as a general regulatory mechanism in skeletal muscle, independent of the canonical calcium signalling pathway.
Fusi et al. (2016) studied Skeletal muscle physiology. Passive stress and calcium concentration changes vs. Zero stress / low calcium conditions was evaluated on Orientation of the myosin regulatory light chain (RLC) C-lobe. Thick filament stress directly controls the orientation of myosin motors and the activation of thick filaments independently of intracellular calcium concentration.
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