June 1, 1977British Journal of Clinical PharmacologyOpen Access

Indirect blood pressure and heart rate measured quickly without observer bias using a semi‐automatic machine (auto‐manometer)‐response to isometric exercise in normal healthy males and its modification by beta‐adrenoceptor blockade.

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Why the study?

Does metoprolol tartrate reduce blood pressure and heart rate responses to isometric exercise in normal healthy males?

Population

6 normal healthy male volunteers

Comparison

Oral administration of metoprolol tartrate 90… vs Placebo and baseline (before drug)

Design

RCT, double-blind

Follow-up

90 min

Authors

GNG. NybergSahlgrenska University Hospital

Discussion

Member takes

Implication

Metoprolol blunts heart rate but not blood pressure rise during isometric exercise in healthy males; extends beta-blocker effects to static effort.

Structured PICO

Does metoprolol tartrate reduce blood pressure and heart rate responses to isometric exercise in normal healthy males?

Population

6 normal healthy male volunteers

Intervention

Oral administration of metoprolol tartrate (doses reported as 0.25 mg, 25 mg, and 100 mg) 90 min before sustained handgrip

Comparator

Placebo and baseline (before drug)

Outcome

Blood pressure and heart rate at rest and during sustained handgrip at 50% of maximal voluntary contractionsurrogate

Metoprolol blunts the heart rate response to isometric exercise but does not alter the blood pressure rise in healthy males.

Cite This Study

G. Nyberg (1977) studied this question.

synapsesocial.com/papers/6a7064fb5d37378ac1dd7b3d https://doi.org/10.1111/j.1365-2125.1977.tb00712.x

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Implication

Metoprolol blunts heart rate but not blood pressure rise during isometric exercise in healthy males; extends beta-blocker effects to static effort.

Indirect blood pressure and heart rate measured quickly without observer bias using a semi‐automatic machine (auto‐manometer)‐response to isometric exercise in normal healthy males and its modification by beta‐adrenoceptor blockade.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Indirect blood pressure and heart rate measured quickly without observer bias using a semi‐automatic machine (auto‐manometer)‐response to isometric exercise in normal healthy males and its modification by beta‐adrenoceptor blockade.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider