Why the study?
Do anthropometric parameters influence the pharmacodynamic effects of metoprolol on vital signs during ergometry in healthy volunteers?
Do anthropometric parameters influence the pharmacodynamic effects of metoprolol on vital signs during ergometry in healthy volunteers?
Anthropometric parameters such as weight and height significantly influence the heart rate response to metoprolol during exercise, which should be considered during exercise testing.
Metoprolol is a widely used beta1-selective beta-blocker in hypertension and tachycardia. The influence on vital signs at rest and during ergometry (exercise heart rate or blood pressure, effect areas above baseline) was investigated in a pilot study with 18 healthy volunteers (mean age 29.1 years) by means of multiple and pairwise correlation analysis. At rest, the difference between predose and day 5 values were not associated with anthropometric characteristics. During ergometry for weight and height significant negative correlations were found corresponding to marked beta-values in the multiple regression models. Therefore heart rate decreases less markedly in slim persons which should be taken into consideration in exercise tests during metoprolol intake.
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Koch et al. (2004) studied this question.
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