Why the study?
Does bolus adenosine administration alter atrial refractoriness in patients with atrial fibrillation?
Population
15 patients with atrial fibrillation
Comparison
Bolus administration of 12 mg of adenosine vs Baseline (before adenosine administration)
Design
Case_series
Follow-up
Transient (seconds during and after bolus administration)
Authors
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May explain adenosine's proarrhythmic AF potential; hypothesis-generating case report requiring prospective validation.
Does bolus adenosine administration alter atrial refractoriness in patients with atrial fibrillation?
Adenosine produces a transient, spatially and temporally inhomogeneous shortening of atrial refractoriness, providing a mechanistic explanation for its potential to induce transient atrial fibrillation.
Botteron et al. (1994) studied this question.
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