Key result
Depression occurred in 24% of patients within six months after ischemic stroke, with female gender, prior depression, and major physical disability identified as significant predictors.
Why the study?
What are the baseline predictors of depression within six months after ischemic stroke?
Cohort (n=251)
What are the baseline predictors of depression within six months after ischemic stroke?
Odds Ratio: 2.4 (95% CI 0.97–5.91)
Female gender, prior depression, major physical disability, prior stroke, recent stressful life events, and pathologic crying are significant predictors of post-stroke depression within six months.
May warrant closer post-stroke depression monitoring in high-risk patients; leaves open whether targeted interventions improve outcomes.
BACKGROUND: Depression negatively affects rehabilitation and quality of life after stroke. Identifying in the acute phase patients at high risk for post-stroke depression would facilitate early detection of depressive symptoms. METHODS: The DEPRESS (Depression Predictors after Ischemic Stroke) study was a prospective cohort study designed to identify baseline predictors of depression occurring within six months after ischemic stroke and high-risk patients for post-stroke depression. All patients without aphasia were screened for depression by a neurologist using the Patient Health Questionnaire, and the diagnosis was confirmed by a psychiatrist with the Mini International Neuropsychiatric Interview. In severely aphasic patients, depression was diagnosed using the Aphasic Depression Rating Scale and the Visual Analog Mood Scale. RESULTS: Depression was present in 61 of 251 (24%) patients enrolled in the DEPRESS study. Female gender, prior history of depression, major physical disability, prior history of stroke, stressful life event exposure in the month preceding stroke onset, and pathologic crying were significant predictors of depression within six months after ischemic stroke. Depression was more frequent in patients with left caudate and/or lenticular nucleus lesion (OR = 2.4, 95% confidence interval, 0.97-5.91), but the difference was not significant. The presence of ≥2 predictors identified the largest proportion of depressed patients (62%) in the smallest proportion of the cohort (36%). CONCLUSION: Female gender, prior history of depression, major physical disability, prior history of stroke, recent stressful life event exposure before stroke, and pathologic crying were significant predictors of post-stroke depression occurring within six months after stroke onset.
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Guiraud et al. (2016) conducted a cohort in Ischemic stroke (n=251). Baseline predictors (e.g., female gender, prior depression, prior stroke, major physical disability) vs. Absence of predictors was evaluated on Depression within six months after ischemic stroke (OR 2.4, 95% CI 0.97-5.91). Depression occurred in 24% of patients within six months after ischemic stroke, with female gender, prior depression, and major physical disability identified as significant predictors.
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