Population
4-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY)
Comparison
High salt diet (8% NaCl) for 4 weeks vs Normal salt diet (0.3% NaCl) for 4 weeks
Design
Preclinical
Follow-up
4 weeks
Authors
Loading...
High salt may impair vascular relaxation via sGC downregulation in hypertensive models; leaves open translation to human salt sensitivity.
Excessive dietary salt impairs vascular relaxation in spontaneously hypertensive rats by downregulating soluble guanylate cyclase and decreasing cyclic GMP production, independent of the eNOS/NO pathway.
Kagota et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: