(1→3)β-d-Glucan Assay Positivity in Patients with Pneumocystis (carinii) jiroveci Pneumonia

Letters3 July 2007(1→3)β-d-Glucan Assay Positivity in Patients with Pneumocystis (carinii) jiroveci PneumoniaFrancisco M. Marty, MD, Sophia Koo, MD, Julie Bryar, BA, and Lindsey R. Baden, MDFrancisco M. Marty, MDFrom Brigham and Women's Hospital, Boston, MA 02115., Sophia Koo, MDFrom Brigham and Women's Hospital, Boston, MA 02115., Julie Bryar, BAFrom Brigham and Women's Hospital, Boston, MA 02115., and Lindsey R. Baden, MDFrom Brigham and Women's Hospital, Boston, MA 02115.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-1-200707030-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Measurement of serum (1→3)β-d-glucan (β-glucan) is now available in the United States as a diagnostic aid for invasive fungal infections in high-risk patients (1, 2). β-Glucan is a cell-wall component of most pathogenic fungi, including Pneumocystis jiroveci (formerly P. carinii) (3). Serum β-glucan positivity in patients with Pneumocystis (carinii) jiroveci pneumonia (PCP) has been reported in Japan (4, 5). Whether the assay licensed in the United States (Fungitell, Associates of Cape Cod, Falmouth, Massachusetts) is reactive in patients with PCP is unknown (1, 2).Objective: To report the results of serum β-glucan testing among patients with a confirmed diagnosis ...References1. Odabasi Z, Mattiuzzi G, Estey E, Kantarjian H, Saeki F, Ridge RJ, et al. Beta-d-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome. Clin Infect Dis. 2004;39:199-205. [PMID: 15307029] CrossrefMedlineGoogle Scholar2. Ostrosky-Zeichner L, Alexander BD, Kett DH, Vazquez J, Pappas PG, Saeki F, et al. Multicenter clinical evaluation of the (1→3) beta-d-glucan assay as an aid to diagnosis of fungal infections in humans. Clin Infect Dis. 2005;41:654-9. [PMID: 16080087] CrossrefMedlineGoogle Scholar3. Matsumoto Y, Matsuda S, Tegoshi T. Yeast glucan in the cyst wall of Pneumocystis carinii. J Protozool. 1989;36:21S-22S. [PMID: 2785184] CrossrefMedlineGoogle Scholar4. Shimizu A, Oka H, Matsuda T, Ozaki S. (1→3)-beta-d glucan is a diagnostic and negative prognostic marker for Pneumocystis carinii pneumonia in patients with connective tissue disease. Clin Exp Rheumatol. 2005;23:678-80. [PMID: 16173245] MedlineGoogle Scholar5. Yasuoka A, Tachikawa N, Shimada K, Kimura S, Oka S. (1→3) beta-d-glucan as a quantitative serological marker for Pneumocystis carinii pneumonia. Clin Diagn Lab Immunol. 1996;3:197-9. [PMID: 8991635] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Brigham and Women's Hospital, Boston, MA 02115.Disclosures: None disclosed. 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