Why the study?
Is lower oxygen delivery 6 hours after oesophagectomy associated with increased hospital mortality and postoperative complications in patients with oesophageal carcinoma?
Is lower oxygen delivery 6 hours after oesophagectomy associated with increased hospital mortality and postoperative complications in patients with oesophageal carcinoma?
Lower oxygen delivery 6 hours after oesophagectomy is associated with an increased risk of postoperative complications and hospital mortality.
Associated with higher mortality after oesophagectomy; leaves open whether goal-directed optimization improves survival in this population.
BACKGROUND: This study was designed to assess the impact of oxygen transport variables on outcome in 115 patients undergoing elective surgery for oesophageal carcinoma. METHODS: Haemodynamic parameters were determined using a Swan-Ganz catheter in all patients on the day before operation, 6 h after operation, and daily for the first 4 days after operation. RESULTS: Oxygen delivery and consumption at 6 h were significantly higher in survivors than in non-survivors. However, oxygen delivery and consumption in both groups did not differ significantly after postoperative day 1. Of 17 patients with oxygen delivery levels lower than 445 ml min-1 m-2 at 6 h, eight died in hospital. Oxygen delivery in patients who developed either an anastomotic leak or severe pneumonia was significantly lower 6 h after surgery. Lower levels of oxygen delivery preceded postoperative complications. CONCLUSION: Oxygen delivery 6 h after oesophagectomy correlates with postoperative complications and may be a determinant of hospital mortality.
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Kusano et al. (1997) studied this question.
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