Key result
Continuous infusion of Angiotensin II in mice infected with Plasmodium berghei decreased parasitemia, delayed the onset of experimental cerebral malaria (p=0.0021), and increased survival (p=0.0087).
Population
5-6 weeks old C57BL/6 mice infected with Plasmodium berghei-ANKA and in vitro P. falciparum cultures.
Comparison
Angiotensin II 100 or 500 ng/kg/min delivered… vs Saline buffer delivered via subcutaneous osmotic…
Design
Preclinical
Follow-up
12 days
Authors
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Hypothesis-generating for angiotensin II in murine malaria; leaves open translation to human cerebral malaria.
p-value: p=0.0021
In a mouse model, continuous infusion of Angiotensin II decreased parasitemia and delayed the onset of experimental cerebral malaria, complementing previous human genetic studies.
Gallego‐Delgado et al. (2015) studied Experimental Cerebral Malaria (n=44). Angiotensin II vs. Saline buffer was evaluated on Incidence of experimental cerebral malaria (p=0.0021). Continuous infusion of Angiotensin II in mice infected with Plasmodium berghei decreased parasitemia, delayed the onset of experimental cerebral malaria (p=0.0021), and increased survival (p=0.0087).
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