February 16, 2017Frontiers in Cellular and Infection MicrobiologyOpen Access

Targeting Angiotensin II Type-1 Receptor (AT1R) Inhibits the Harmful Phenotype of Plasmodium-Specific CD8+ T Cells during Blood-Stage Malaria

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Why the study?

Does AT1R inhibition reduce the harmful activation and expansion of Plasmodium-specific CD8+ T cells during blood-stage malaria in mice?

Population

Six- to eight-week-old male C57BL/6 mice infected with transgenic Plasmodium berghei ANKA expressing…

Comparison

Genetic knockout of AT1R or pharmacological… vs Wild-type (WT) OT-I cells and vehicle treatment.

Design

Preclinical

Follow-up

6 days

Authors

JSJoão Luiz Silva‐FilhoUniversity of Glasgow CCCelso Caruso‐NevesUniversidade Federal do Rio de Janeiro APAna Acácia S. PinheiroUniversidade Federal do Rio de Janeiro

Discussion

Member takes

Implication

AT1R inhibition may curb CD8+ T-cell activation in malaria; hypothesis-generating in mice, human relevance unknown.

Structured PICO

Does AT1R inhibition reduce the harmful activation and expansion of Plasmodium-specific CD8+ T cells during blood-stage malaria in mice?

Population

Six- to eight-week-old male C57BL/6 mice (WT, OT-I TCR transgenic, and AT1R-/-) infected with transgenic Plasmodium berghei ANKA expressing ovalbumin (OVA-PbA).

Intervention

Genetic knockout of AT1R (AT1R-/- OT-I cells) or pharmacological treatment with losartan (20 mg/kg/day) or captopril (20 mg/kg/day) by gavage for 6 days.

Comparator

Wild-type (WT) OT-I cells and vehicle treatment.

Outcome

Expansion, activation (CD69, CD160, CD44), and exhaustion profiles of Plasmodium-specific CD8+ T cells at day 6 post-infection.surrogate

Inhibition of AT1R signaling, either genetically or pharmacologically, reduces the harmful activation and expansion of Plasmodium-specific CD8+ T cells during blood-stage malaria.

Cite This Study

Silva‐Filho et al. (2017) studied this question.

synapsesocial.com/papers/6a8864efd03e68c3c9a55299 https://doi.org/10.3389/fcimb.2017.00042

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February 16, 2017Frontiers in Cellular and Infection MicrobiologyOpen Access

Targeting Angiotensin II Type-1 Receptor (AT1R) Inhibits the Harmful Phenotype of Plasmodium-Specific CD8+ T Cells during Blood-Stage Malaria

View Full Paper

Ask AI

Bookmark

Why the study?

Does AT1R inhibition reduce the harmful activation and expansion of Plasmodium-specific CD8+ T cells during blood-stage malaria in mice?

Population

Six- to eight-week-old male C57BL/6 mice infected with transgenic Plasmodium berghei ANKA expressing…

Comparison

Genetic knockout of AT1R or pharmacological… vs Wild-type (WT) OT-I cells and vehicle treatment.

Design

Preclinical

Follow-up

6 days

Authors

JSJoão Luiz Silva‐FilhoUniversity of Glasgow CCCelso Caruso‐NevesUniversidade Federal do Rio de Janeiro APAna Acácia S. PinheiroUniversidade Federal do Rio de Janeiro

Discussion

Member takes

Implication

AT1R inhibition may curb CD8+ T-cell activation in malaria; hypothesis-generating in mice, human relevance unknown.

Structured PICO

Does AT1R inhibition reduce the harmful activation and expansion of Plasmodium-specific CD8+ T cells during blood-stage malaria in mice?

Population

Six- to eight-week-old male C57BL/6 mice (WT, OT-I TCR transgenic, and AT1R-/-) infected with transgenic Plasmodium berghei ANKA expressing ovalbumin (OVA-PbA).

Intervention

Genetic knockout of AT1R (AT1R-/- OT-I cells) or pharmacological treatment with losartan (20 mg/kg/day) or captopril (20 mg/kg/day) by gavage for 6 days.

Comparator

Wild-type (WT) OT-I cells and vehicle treatment.

Outcome

Expansion, activation (CD69, CD160, CD44), and exhaustion profiles of Plasmodium-specific CD8+ T cells at day 6 post-infection.surrogate

Inhibition of AT1R signaling, either genetically or pharmacologically, reduces the harmful activation and expansion of Plasmodium-specific CD8+ T cells during blood-stage malaria.

Cite This Study

Silva‐Filho et al. (2017) studied this question.

synapsesocial.com/papers/6a8864efd03e68c3c9a55299 https://doi.org/10.3389/fcimb.2017.00042

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