Key result
In a 3D mathematical model of human cardiac tissue, scroll-wave dynamics and their tendency to anchor to inhomogeneities depend delicately upon the degree of muscle-fiber rotation.
In a 3D mathematical model of human cardiac tissue, the combination of muscle-fiber rotation and inhomogeneities significantly alters scroll-wave dynamics, providing insights into the mechanisms of ventricular fibrillation.
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Model shows fiber rotation modulates scroll-wave anchoring; hypothesis-generating for VF mechanisms, needs experimental validation.
Majumder et al. (2011) studied Cardiac arrhythmias. Fiber rotation and inhomogeneities in a 3D TNNP mathematical model vs. Homogeneous model without fiber rotation was evaluated on Scroll-wave dynamics (anchoring, meandering, and break-up). In a 3D mathematical model of human cardiac tissue, scroll-wave dynamics and their tendency to anchor to inhomogeneities depend delicately upon the degree of muscle-fiber rotation.
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