Key result
Myocardial thickness and anisotropy govern LV scroll wave filament tension, driving negative filaments toward the apex.
Why the study?
Most studies of scroll wave filament dynamics were performed in simple geometries with generic anisotropy, lacking analysis in an anatomical model of the human left ventricle.
In a computational model of the human left ventricle, scroll wave filament dynamics are influenced by filament tension, myocardial wall thickness, and tissue anisotropy, with filaments generally tending toward the LV apex.
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Anatomical anisotropy may direct scroll wave filaments toward the LV apex; leaves open whether this shapes clinical arrhythmia dynamics.
Pravdin et al. (2015) studied Cardiac arrhythmias. Analytical model of fibre structure and anatomy of the left ventricle was evaluated on Dynamics of scroll wave filaments. In an anatomical model of the human left ventricle, positive scroll wave filament tension is determined by myocardial wall thickness and anisotropy, while negative tension buckles towards the apex.