Key result
Numerical simulation using the Luo-Rudy phase 1 model demonstrated the existence of negative filament tension instability, a potential mechanism for scroll wave disorganization and arrhythmogenesis.
This computational study confirms the existence of negative filament tension instability in a widely used cardiac electrophysiology model, providing theoretical insights into the mechanisms of ventricular fibrillation.
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No immediate clinical implications for arrhythmia management; leaves open the role of filament tension instability in human ventricular fibrillation.
Scroll waves are vortices that occur in three-dimensional excitable media. Scroll waves have been observed in a variety of systems including cardiac tissue, where they are associated with cardiac arrhythmias. The disorganization of scroll waves into chaotic behavior is thought to be the mechanism of ventricular fibrillation, which lethality is widely known. One of the possible mechanisms of scroll wave instability is negative filament tension, which was studied theoretically using low-dimensional models of excitable medium. In this article we perform a numerical study of negative filament tension using the Luo-Rudy phase 1 model, which is widely used in cardiac electrophysiology. We show that this instability exists in this model, study its manifestation and discuss its relation to cardiac arrhythmogenesis.
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Alonso et al. (2007) studied Cardiac arrhythmias and ventricular fibrillation. Numerical simulation of negative filament tension was evaluated on Existence and manifestation of negative filament tension instability. Numerical simulation using the Luo-Rudy phase 1 model demonstrated the existence of negative filament tension instability, a potential mechanism for scroll wave disorganization and arrhythmogenesis.
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