Key result
Numerical integration of the Luo-Rudy model demonstrated the expansion of scroll rings (low curvature negative filament tension) in a cardiac tissue medium with high excitability.
Demonstrates that negative filament tension, a mechanism for turbulence onset, can occur at high excitability in normal cardiac tissue models.
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Does not alter arrhythmia management; leaves open whether negative filament tension drives turbulence in vivo.
One of the fundamental mechanisms for the onset of turbulence in 3D excitable media is negative filament tension. Thus far, negative tension has always been obtained in media under low excitability. For this reason, its application to normal (nonischemic) cardiac tissue has been questionable, as such cardiac turbulence typically occurs at high excitability. Here, we report expansion of scroll rings (low curvature negative filament tension) in a medium with high excitability by numerical integration of the Luo-Rudy model of cardiac tissue. We discuss the relation between negative tension and the meandering of 2D spiral waves and the possible applications to cardiac modeling.
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Alonso et al. (2008) studied Cardiac tissue modeling. High excitability medium in the Luo-Rudy model was evaluated on Expansion of scroll rings (low curvature negative filament tension). Numerical integration of the Luo-Rudy model demonstrated the expansion of scroll rings (low curvature negative filament tension) in a cardiac tissue medium with high excitability.
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