Key result
Numerical simulations demonstrated that cardiac tissue anisotropy destabilizes vortex filaments in the Beeler-Reuter model, whereas it does not destabilize filaments in the Luo-Rudy model.
The effect of cardiac tissue anisotropy on vortex filament instability is model-dependent, occurring in the Beeler-Reuter model but not the Luo-Rudy model.
Model-specific anisotropy effects on filaments urge caution extrapolating simulations; leaves open anisotropy's role in reentry across models.
The role of cardiac tissue anisotropy in the breakup of vortex filaments is studied using two detailed cardiac models. In the Beeler-Reuter model, modified to produce stable spiral waves in two dimensions, we find that anisotropy can destabilize a vortex filament in a parallelepipedal slab of tissue. The mechanisms of the instability are similar to the ones reported in previous work on a simplified cardiac model by Fenton and Karma [Chaos 8, 20 (1998)]. In the Luo-Rudy model, also modified to produce stable spiral waves in two dimensions, we find that anisotropy does not destabilize filaments. A possible explanation for this model-dependent behavior based on spiral tip trajectories is offered.
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Wouter‐Jan Rappel (2001) studied Cardiac tissue anisotropy and vortex filament breakup. Numerical simulation (Beeler-Reuter and Luo-Rudy models) was evaluated on Vortex filament destabilization. Numerical simulations demonstrated that cardiac tissue anisotropy destabilizes vortex filaments in the Beeler-Reuter model, whereas it does not destabilize filaments in the Luo-Rudy model.
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