Key result
Propofol-based total intravenous anesthesia significantly reduced extubation time compared to desflurane anesthesia (8.5 vs 9.4 minutes, P=0.04) in patients undergoing open major upper abdominal surgery.
Why the study?
Does propofol-based TIVA reduce extubation time compared to desflurane anesthesia in patients undergoing open major upper abdominal surgery?
Observational (n=343)
No
Does propofol-based TIVA reduce extubation time compared to desflurane anesthesia in patients undergoing open major upper abdominal surgery?
Absolute Event Rate: 8.5% vs 9.4%
p-value: p=0.04
Propofol-based TIVA provides a statistically significant but clinically marginal reduction in extubation time compared with desflurane anesthesia in open major upper abdominal surgery, without improving overall OR efficiency.
May support faster-recovery protocols in abdominal surgery; hypothesis-generating and requires randomized confirmation before practice change.
Reducing anesthesia-controlled time (ACT) may improve operation room (OR) efficiency result from different anesthetic techniques. However, the information about the difference in ACT between desflurane (DES) anesthesia and propofol-based total intravenous anesthesia (TIVA) techniques for open major upper abdominal surgery under general anesthesia (GA) is not available in the literature.This retrospective study uses our hospital database to analyze the ACT of open major upper abdominal surgery without liver resection after either desflurane/fentanyl-based anesthesia or TIVA via target-controlled infusion with fentanyl/propofol from January 2010 to December 2011. The various time intervals including waiting for anesthesia time, anesthesia time, surgical time, extubation time, exit from OR after extubation, total OR time, and postanesthetic care unit (PACU) stay time and percentage of prolonged extubation (≥15 minutes) were compared between these 2 anesthetic techniques.We included data from 343 patients, with 159 patients receiving TIVA and 184 patients receiving DES. The only significant difference is extubation time, TIVA was faster than the DES group (8.5 ± 3.8 vs 9.4 ± 3.7 minutes; P = 0.04). The factors contributed to prolonged extubation were age, gender, body mass index, DES anesthesia, and anesthesia time.In our hospital, propofol-based TIVA by target-controlled infusion provides faster emergence compared with DES anesthesia; however, it did not improve OR efficiency in open major abdominal surgery. Older, male gender, higher body mass index, DES anesthesia, and lengthy anesthesia time were factors that contribute to extubation time.
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Lai et al. (2017) conducted an observational in Open major upper abdominal surgery (n=343). Propofol-based total intravenous anesthesia (TIVA) vs. Desflurane (DES) anesthesia was evaluated on Extubation time (p=0.04). Propofol-based total intravenous anesthesia significantly reduced extubation time compared to desflurane anesthesia (8.5 vs 9.4 minutes, P=0.04) in patients undergoing open major upper abdominal surgery.
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