What question did this study set out to answer?

To quantify and compare epithelial and inflammatory cell subtypes in the upper and lower airways of individuals with cystic fibrosis versus healthy control subjects.

January 1, 1996American Journal of Respiratory and Critical Care Medicine

Quantitative Assessment of the Epithelial and Inflammatory Cell Populations in Large Airways of Normals and Individuals With Cystic Fibrosis

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Authors

CDClaire DanelUniversité Claude Bernard Lyon 1 SESerpil C. ErzurumCleveland State University NMNoel G. McElvaneyRoyal College of Surgeons in Ireland

Discussion

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Implication

Comparative study demonstrates marked neutrophil inflammation and reduced ciliated cells in bronchial airways of cystic fibrosis patients, indicating divergent epithelial disease across airway sites.

Key Points

To quantify and compare epithelial and inflammatory cell subtypes in the upper and lower airways of individuals with cystic fibrosis versus healthy control subjects.
Collected nasal brushings, bronchial brushings, and bronchial biopsies from individuals with cystic fibrosis and healthy normal subjects.
Quantified and compared epithelial subtypes (including ciliated and basal cells) and inflammatory cell populations across sampling techniques and anatomical locations.
Bronchial brushings in cystic fibrosis yielded a 2.5-fold increase in recovered cells compared to healthy controls, driven predominantly by high neutrophil numbers.
The proportion of ciliated cells was lower in cystic fibrosis bronchial brushings than in controls, whereas nasal brushings showed similar epithelial subtype distributions between groups.
Bronchial biopsies yielded a higher proportion of basal cells than brushings, with otherwise similar relative proportions of recovered epithelial cells.

Cite This Study

Danel et al. (1996) studied this question.

synapsesocial.com/papers/6a706b03abc331a858079957 https://doi.org/10.1164/ajrccm.153.1.8542144

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Implication

Comparative study demonstrates marked neutrophil inflammation and reduced ciliated cells in bronchial airways of cystic fibrosis patients, indicating divergent epithelial disease across airway sites.

Quantitative Assessment of the Epithelial and Inflammatory Cell Populations in Large Airways of Normals and Individuals With Cystic Fibrosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Quantitative Assessment of the Epithelial and Inflammatory Cell Populations in Large Airways of Normals and Individuals With Cystic Fibrosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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