What question did this study set out to answer?

To compare inflammatory cells and cytokine concentrations between the upper and lower respiratory tracts in young children with cystic fibrosis and disease controls.

March 1, 1997The Journal of Infectious DiseasesOpen Access

Nasal and Bronchoalveolar Lavage Fluid Cytokines in Early Cystic Fibrosis

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Authors

TNTerry L. NoahUniversity of North Carolina at Charlotte HBHenry R. BlackRutgers, The State University of New Jersey PCPing‐Chia ChengUniversity of Science and Technology

Discussion

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Implication

Observational study reveals elevated lower airway interleukin-8 in young cystic fibrosis patients, indicating early inflammation is restricted to the lower respiratory tract.

Key Points

To compare inflammatory cells and cytokine concentrations between the upper and lower respiratory tracts in young children with cystic fibrosis and disease controls.
Obtained nasal lavage fluid (NLF) and bronchoalveolar lavage fluid (BALF) from children with and without cystic fibrosis undergoing bronchoscopy for clinical indications.
Quantified inflammatory cells along with cytokine concentrations, including interleukin (IL)-8, IL-6, and IL-10, standardizing IL-8 levels to bacterial colony counts.
Nasal lavage fluid showed no significant differences in inflammatory cell counts or cytokine concentrations between cystic fibrosis patients and controls.
Bronchoalveolar IL-8 levels were markedly elevated in infected children with cystic fibrosis compared with both infected and uninfected controls, remaining elevated after standardization to bacterial counts.
Bronchoalveolar IL-6 was modestly higher in infected cystic fibrosis than uninfected controls, whereas IL-10 did not differ across groups and nasal IL-8 did not correlate with lower airway IL-8.

Cite This Study

Noah et al. (1997) studied this question.

synapsesocial.com/papers/6a90df0f17bbbfe73e7448dd https://doi.org/10.1093/infdis/175.3.638

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March 1, 1997The Journal of Infectious DiseasesOpen Access

Nasal and Bronchoalveolar Lavage Fluid Cytokines in Early Cystic Fibrosis

View Full Paper

Ask AI

Bookmark

Authors

TNTerry L. NoahUniversity of North Carolina at Charlotte HBHenry R. BlackRutgers, The State University of New Jersey PCPing‐Chia ChengUniversity of Science and Technology

Discussion

Member takes

Implication

Observational study reveals elevated lower airway interleukin-8 in young cystic fibrosis patients, indicating early inflammation is restricted to the lower respiratory tract.

Key Points

To compare inflammatory cells and cytokine concentrations between the upper and lower respiratory tracts in young children with cystic fibrosis and disease controls.
Obtained nasal lavage fluid (NLF) and bronchoalveolar lavage fluid (BALF) from children with and without cystic fibrosis undergoing bronchoscopy for clinical indications.
Quantified inflammatory cells along with cytokine concentrations, including interleukin (IL)-8, IL-6, and IL-10, standardizing IL-8 levels to bacterial colony counts.
Nasal lavage fluid showed no significant differences in inflammatory cell counts or cytokine concentrations between cystic fibrosis patients and controls.
Bronchoalveolar IL-8 levels were markedly elevated in infected children with cystic fibrosis compared with both infected and uninfected controls, remaining elevated after standardization to bacterial counts.
Bronchoalveolar IL-6 was modestly higher in infected cystic fibrosis than uninfected controls, whereas IL-10 did not differ across groups and nasal IL-8 did not correlate with lower airway IL-8.

Cite This Study

Noah et al. (1997) studied this question.

synapsesocial.com/papers/6a90df0f17bbbfe73e7448dd https://doi.org/10.1093/infdis/175.3.638

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