Key result
Nitrous oxide (N2O) is an inorganic inhalation agent that does not undergo biotransformation, does not bind to hemoglobin, and is rapidly eliminated due to its low solubility.
Properties support rapid-recovery anesthesia; leaves open comparative trials versus modern agents.
1.1. N 2 O, dinitrogen monoxide, nitrogen protoxide N 2 O is an inorganic inhalation agent that is colorless, odorless or sweet-smelling, non-irritating to tissues, non-flammable but capable of supporting (4). It does not undergo biotransformation, does not bind to hemoglobin, and is transported by dissolving in the blood (4). Its elimination is the opposite of uptake and distribution. Its low solubility enables rapid elimination (4,5). N 2 O, which was defined by Sir Humphry Davy as "laughing/ giggle gas", was not used for anesthesia in the first half of the 19th century, but began to be used for analgesic purposes in
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Çiçek et al. (2022) reported a review. Nitrous oxide (N2O) was evaluated. Nitrous oxide (N2O) is an inorganic inhalation agent that does not undergo biotransformation, does not bind to hemoglobin, and is rapidly eliminated due to its low solubility.
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