Why the study?
Does closed circuit desflurane anaesthesia reduce induction time and anaesthetic consumption compared to semi-closed circuit in female patients undergoing gynaecological surgery?
Does closed circuit desflurane anaesthesia reduce induction time and anaesthetic consumption compared to semi-closed circuit in female patients undergoing gynaecological surgery?
Closed-circuit desflurane anaesthesia using the Zeus machine allows for faster induction and lower anaesthetic consumption without compromising haemodynamic stability or recovery.
Closed-circuit desflurane shortens induction time and reduces consumption versus semi-closed circuit; supports adoption in gynecologic surgery while extending low-flow anesthesia data.
This clinical study compared induction time, consumed anaesthetic dose, and haemodynamic and recovery profiles when using a new type of multifunctional anaesthesia machine (Zeus) in semi-closed or closed circuit modes. Sixty female patients undergoing gynaecological surgery were randomly assigned to three groups and received desflurane anaesthesia through a semi-closed circuit (SCC) at fresh gas flow rates of 4 l/min (SCC 4 l/min) or 2 l/min (SCC 2 l/min), or through a closed circuit (CC). Anaesthesia was maintained at the minimum alveolar concentration for blocking the adrenergic response to painful stimulus (MAC(BAR)) (4.6% end-tidal desflurane) during each operation. The time required to reach MAC(BAR) was significantly shorter and the dose of desflurane was significantly smaller in the CC group compared with the other groups. There were no differences in haemodynamic and recovery profiles between the groups. It is concluded that the CC mode allowed a faster and more reliable induction, lower anaesthetic consumption and stable haemodynamic and recovery profiles.
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Park et al. (2010) studied this question.
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