October 1, 2002Anesthesia & Analgesia
Remifentanil, Fentanyl, and Cardiac Surgery: A Double-Blinded, Randomized, Controlled Trial of Costs and Outcomes
Why the study?
Does remifentanil infusion improve time to tracheal extubation and clinical outcomes in cardiac surgical patients compared to fentanyl?
Population
77 cardiac surgical patients (undergoing coronary artery bypass graft surgery)
Comparison
Remifentanil infusion at 0.83 μg/kg/min vs Fentanyl bolus, small dose at 12 μg/kg or…
Design
RCT, randomly allocated, double-blinded
Authors
Discussion
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Implication
Remifentanil supports fast-track extubation comparable to small-dose fentanyl; extends RCT evidence for opioid dosing in cardiac anesthesia.
Structured PICO
Does remifentanil infusion improve time to tracheal extubation and clinical outcomes in cardiac surgical patients compared to fentanyl?
P
Population
77 cardiac surgical patients (undergoing coronary artery bypass graft surgery)
I
Intervention
Remifentanil infusion at 0.83 μg/kg/min
C
Comparator
Fentanyl bolus, small dose at 12 μg/kg (Group FLD) or moderate dose at 24 μg/kg (Group FMD)
O
Outcome
Median time to tracheal extubation
Remifentanil during cardiac surgery results in comparable extubation times to small-dose fentanyl and reduces postoperative MI and hypertension, though it increases hypotension.
Cite This Study
Myles et al. (2002) studied this question.