Why the study?
Does a remifentanil and propofol sedation regimen reduce time to ICU discharge and extubation in post-cardiac surgery patients compared to midazolam and fentanyl?
Population
80 patients who had undergone cardiac surgery, requiring postoperative sedation in the ICU for 12 to 72 hours
Comparison
Remifentanil (6 to max 60 microg kg h)… vs Midazolam (0.02 to 0.2 mg kg h) and fentanyl…
Design
RCT, randomised, open-label
Follow-up
until ICU discharge
Authors
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Supports remifentanil/propofol sedation to expedite eligible ICU discharge after cardiac surgery at equal cost; reinforces RCT evidence versus midazolam/fentanyl.
Does a remifentanil and propofol sedation regimen reduce time to ICU discharge and extubation in post-cardiac surgery patients compared to midazolam and fentanyl?
A remifentanil-based sedation regimen supplemented with propofol significantly reduces time on mechanical ventilation and allows earlier ICU discharge compared to midazolam/fentanyl in post-cardiac surgery patients, without increasing costs.
Muellejans et al. (2006) studied this question.
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