Key result
Amateur boxing was associated with significantly higher median serum levels of neuron-specific enolase compared to healthy controls (11 vs 4.8 ng/mL, p=0.014) after a 2-month resting period.
Why the study?
Does amateur boxing result in sustained release of brain-specific proteins to the peripheral circulation compared to healthy controls?
Case-Control
Does amateur boxing result in sustained release of brain-specific proteins to the peripheral circulation compared to healthy controls?
Absolute Event Rate: 11% vs 4.8%
p-value: p=0.014
Amateur boxing is associated with sustained elevation of serum neuron-specific enolase, suggesting chronic neuronal injury from repetitive head trauma.
May signal chronic neuronal injury risk in amateur boxers; hypothesis-generating for NSE monitoring in contact sports.
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Zetterberg et al. (2009) conducted a case-control in Chronic neuronal injury. Amateur boxing (repetitive head trauma) vs. Healthy controls without any history of head trauma was evaluated on Serum levels of neuron-specific enolase (NSE) in ng/mL (p=0.014). Amateur boxing was associated with significantly higher median serum levels of neuron-specific enolase compared to healthy controls (11 vs 4.8 ng/mL, p=0.014) after a 2-month resting period.
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