Key result
A 30-minute session of high-intensity boxing or kick-boxing exercise significantly increased serum levels of ischemia-modified albumin, brain natriuretic peptide, and copeptin in professional athletes.
Why the study?
Combat sports have a high incidence of traumatic brain injury, and the study aimed to evaluate exercise-induced variations of serum ischemia-modified albumin, brain natriuretic peptide, and copeptin.
Does an exercise program involving combat sports increase serum IMA, BNP, and copeptin levels in male boxers and kick boxers?
Observational (n=66)
No
Does an exercise program involving combat sports increase serum IMA, BNP, and copeptin levels in male boxers and kick boxers?
Combat sports exercise significantly increases serum IMA, BNP, and copeptin, suggesting these may serve as candidate biomarkers for exercise-related traumatic brain injuries.
Answers are grounded in this paper and cite their sources.
Exercise-induced rises in IMA, BNP, and copeptin may confound brain-injury biomarker interpretation in combat athletes; leaves open diagnostic utility pending validation.
Introduction: boxing and kick boxing are combat sports that can cause severe head, neck, face and hand injuries during fighting. Then, traumatic brain injury (TBI) incidence is high in these sports. Ischemia-modified albumin (IMA), brain natriuretic peptide (BNP) and copeptin have diagnostic and prognostic value for cardiac and non-cardiac ischemic events. The purpose of this study is to evaluate exercise-induced variations of serum IMA, BNP and copeptin. Methods: twenty male boxers, twenty-three male kick boxers and twenty-three age-matched male were enrolled in the study. Health assessment data were analysed. Boxers and kick boxers underwent an exercise program including training plus fighting matches. Serum samples were collected in the pre- and post-exercise periods. Serum IMA, BNP and copeptin concentrations were measured in these specimens using ELISA reagents. Results: comparative analysis of analytes before and after exercise showed that exercise significantly increased serum IMA, BNP and copeptin levels both in boxers and kick boxers. Conclusion: in conclusion, IMA, BNP and copeptin levels may be candidate biomarkers for exercise-related traumatic brain injuries. The identification of new biomarkers in patients with acute and chronic neurological disorders is of considerable interest to clinicians. Then, further studies should be conducted to evaluate the possible role of IMA, BNP and copeptin in TBI pathophysiology.
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Memmedov et al. (2022) conducted an observational in Healthy athletes (boxers and kick-boxers) (n=66). High-intensity exercise (boxing/kick-boxing training and matches) vs. Pre-exercise baseline was evaluated on Serum ischemia-modified albumin (IMA) levels in boxers (p=<0.001). A 30-minute session of high-intensity boxing or kick-boxing exercise significantly increased serum levels of ischemia-modified albumin, brain natriuretic peptide, and copeptin in professional athletes.
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