Comparing the Effects of Sevoflurane and Desflurane on Intracranial Pressure in Patients Undergoing Laparoscopic Cholecystectomy Via Ultrasonographic Measurement of the Optic Nerve Sheath Diameter

Objective: Anesthetics have various effects on intracranial pressure (ICP).We aimed to compare the effects of sevoflurane and desflurane on intracranial pressure during laparoscopic cholecystectomy. Methods:After obtaining ethical approval and patients' informed consent, 69 patients scheduled for laparoscopic cholecystectomy were randomized into Group-S and Group-D.Demographic data, hemodynamics, and ultrasonographic optic nerve sheath diameter (ONSD) values were recorded.Patients were administered propofol, fentanyl, and rocuronium for induction of anesthesia.Anesthesia was maintained by administering sevoflurane in Group-S, desflurane in Group-D, and remifentanil infusion.The respiratory rate was adjusted, with end-tidal carbon dioxide (ETCO 2 ) values of 35-40 mmHg.The ONSD measurements, hemodynamics, and ETCO 2 levels were recorded at 5 minutes after induction (T1), 3 minutes after creating pneumoperitoneum and reverse Trendelenburg position (T2), 20 minutes of pneumoperitoneum (T3), and 5 minutes after terminating pneumoperitoneum (T4).All parameters were recorded by an anesthesiologist blinded to the groups.Results: Patients had similar demographic data, intraoperative hemodynamic parameters, SpO 2 , and end-tidal CO 2 levels.There was no difference between the groups in ONSD measured at T0, T1, T2, T3, and T4.Intragroup comparisons revealed that the ONSD was higher at all measurement times than the baseline in both groups. Conclusion:Sevoflurane and desflurane had similar effects on ICP during laparoscopic cholecystectomy, and the intraoperative ICP was higher than the baseline in both groups.