Why the study?
Does desflurane compared to isoflurane preserve baroreceptor reflex control of heart rate or sympathetic nerve activity in humans?
Population
18 human volunteers
Comparison
Desflurane anesthesia at 0.5, 1.0, and 1.5 MAC vs Isoflurane anesthesia at 0.5, 1.0, and 1.5 MAC
Authors
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Baroreflex differences do not explain HR/SNA responses between agents; leaves open mechanisms of anesthetic-specific autonomic effects.
Does desflurane compared to isoflurane preserve baroreceptor reflex control of heart rate or sympathetic nerve activity in humans?
Differences in heart rate and sympathetic nerve activity responses between desflurane and isoflurane are not explained by disparate effects on baroreceptor reflex control.
Muzi et al. (1995) studied this question.
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