Key result
Sevoflurane and desflurane similarly depressed baroreflex-mediated control of heart rate and blood pressure, increasing the delay of systolic blood pressure response from 3.5 to 4.3 s.
Why the study?
Does sevoflurane compared to desflurane differentially affect short-term baroreflex regulation of arterial blood pressure in healthy patients?
Population
40 ASA physical status I patients, aged 20 to 42 yr
Comparison
1.0 minimum alveolar anesthetic concentration of… vs 1.0 minimum alveolar anesthetic concentration of…
Design
RCT, randomly assigned
Follow-up
20 min after anesthesia induction
Authors
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Clinicians may select either agent without baroreflex concerns; confirms equivalence in this RCT and supports broader volatile comparisons.
RCT (n=40)
randomly assigned
Does sevoflurane compared to desflurane differentially affect short-term baroreflex regulation of arterial blood pressure in healthy patients?
Sevoflurane and desflurane similarly depress baroreflex-mediated short-term control of heart rate and blood pressure in healthy patients.
Keyl et al. (2002) conducted an RCT in Anesthesia (n=40). Sevoflurane vs. Desflurane was evaluated on Short-term baroreflex regulation of arterial blood pressure. Sevoflurane and desflurane similarly depressed baroreflex-mediated control of heart rate and blood pressure, increasing the delay of systolic blood pressure response from 3.5 to 4.3 s.
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