Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 2001Anesthesia & Analgesia

The Recovery Profile of Baroreflex Control of Heart Rate After Isoflurane or Sevoflurane Anesthesia in Humans

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does isoflurane or sevoflurane anesthesia differ in the recovery profile of baroreflex control of heart rate in healthy volunteers?

Population

20 healthy volunteers not undergoing surgery

Comparison

Isoflurane or Sevoflurane vs Conscious baseline and comparison between the…

Design

RCT, randomized to receive either isoflurane or sevoflurane (n = 10 each)

Follow-up

180 min after emergence from general anesthesia

Authors

GNGo NagasakiAkita University HospitalMTMakoto TanakaKanazawa UniversityTNToshiaki NishikawaAkita University

Discussion

Loading...

Member takes

Overview

Anesthetists should monitor for baroreflex impairment up to 2 hours post-anesthesia; this RCT confirms equivalent recovery with isoflurane or sevoflurane.

Structured PICO

Does isoflurane or sevoflurane anesthesia differ in the recovery profile of baroreflex control of heart rate in healthy volunteers?

P
Population
20 healthy volunteers not undergoing surgery
I
Intervention
Isoflurane (end-tidal 1.3% in air and oxygen) or Sevoflurane (end-tidal 2.0% in air and oxygen)
C
Comparator
Conscious baseline and comparison between the two anesthetic groups
O
Outcome
Baroreflex sensitivity (assessed by R-R intervals and systolic blood pressure changes triggered by phenylephrine and nitroprusside)surrogate

Full recovery of baroreflex function requires 2 hours after isoflurane or sevoflurane anesthesia, with similar recovery characteristics for both agents.

Cite This Study

Nagasaki et al. (2001) studied this question.

synapsesocial.com/papers/6a72be0087f921057128a88fhttps://doi.org/10.1097/00000539-200111000-00012
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sevoflurane Speeds Recovery of Baroreflex Control of Heart Rate After Minor Surgical Procedures Compared with Isoflurane1999 · 18 citations
  2. 2Sevoflurane Speeds Recovery of Baroreflex Control of Heart Rate After Minor Surgical Procedures Compared with Isoflurane1999 · 16 citations
  3. 3Sinusoidal Neck Suction for Evaluation of Baroreflex Sensitivity During Desflurane and Sevoflurane Anesthesia2002 · 13 citations
  4. 4The Concentration-Dependent Effects of General Anesthesia on Spontaneous Baroreflex Indices and Their Correlations with Pharmacological Gains2005 · 18 citations
  5. 5Baroreceptor Reflex Control of Heart Rate during Isoflurane Anesthesia in Humans1984 · 148 citations