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April 14, 2005Anesthesia & Analgesia

The Concentration-Dependent Effects of General Anesthesia on Spontaneous Baroreflex Indices and Their Correlations with Pharmacological Gains

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Why the study?

Does sevoflurane anesthesia depress spontaneous baroreflex indices compared to conscious baseline in healthy volunteers?

Population

9 healthy volunteers

Comparison

Sevoflurane anesthesia vs Conscious baseline value (awake condition)

Design

Other, random sequences for sevoflurane concentrations

Follow-up

3 hours after anesthesia

Authors

MTMakoto TanakaTNToshiaki Nishikawa

Discussion

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Overview

Sevoflurane may depress spontaneous baroreflex indices in volunteers; hypothesis-generating for their validity as surrogates during anesthesia.

Structured PICO

Does sevoflurane anesthesia depress spontaneous baroreflex indices compared to conscious baseline in healthy volunteers?

P
Population
9 healthy volunteers
I
Intervention
Sevoflurane anesthesia (end-tidal concentrations of 0.7%, 1.4%, and 2.0% administered in random sequences)
C
Comparator
Conscious baseline value (awake condition)
O
Outcome
Spontaneous baroreflex (SBR) indices (sequence method, α-index, and low-frequency transfer function)surrogate

Spontaneous baroreflex indices are depressed by sevoflurane anesthesia and are inadequate surrogates for pharmacological baroreflex gain during anesthesia.

Cite This Study

Tanaka et al. (2005) studied this question.

synapsesocial.com/papers/6a720697ac440176ef2a7a54https://doi.org/10.1213/01.ane.0000148694.23165.f3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Recovery Profile of Baroreflex Control of Heart Rate After Isoflurane or Sevoflurane Anesthesia in Humans2001 · 58 citations
  2. 2Sevoflurane Speeds Recovery of Baroreflex Control of Heart Rate After Minor Surgical Procedures Compared with Isoflurane1999 · 16 citations
  3. 3Baroreceptor Reflex Control of Heart Rate during Isoflurane Anesthesia in Humans1984 · 148 citations
  4. 4Spontaneous Cardiac Baroreflex in Humans1995 · 391 citations
  5. 5Human sympathetic and vagal baroreflex responses to sequential nitroprusside and phenylephrine1999 · 295 citations