Key result
Sevoflurane anesthesia significantly depressed all measured indices of spontaneous baroreflex sensitivity, including sequence BRS which decreased from 15.2 to 2.7 ms/mmHg (P<0.001).
Why the study?
Does sevoflurane anesthesia affect spontaneous baroreflex sensitivity (SBRS)?
Observational (n=50)
No
Does sevoflurane anesthesia affect spontaneous baroreflex sensitivity (SBRS)?
Absolute Event Rate: 2.7% vs 15.2%
p-value: p=<0.001
This study evaluates the physiological impact of sevoflurane anesthesia on spontaneous baroreflex sensitivity using noninvasive computer analysis methods.
Sevoflurane-associated baroreflex depression may warrant hemodynamic vigilance; hypothesis-generating and should not yet change practice.
In contrast to classic drug injection method, various types of noninvasive spontaneous baroreflex sensitivity (SBRS) methods have been developed using the computer analysis of the spontaneous fluctuation of heart rate and arterial blood pressure for baroreflex evaluation. In this study, we evaluated the effects of sevoflurane anesthesia on SBRS by comparing various SBRS estimates and their correlations before and after sevoflurane anesthesia.
No takes yet. Share an insight, caveat, or question.
Kang et al. (2007) conducted an observational in Healthy patients scheduled for laparotomy (n=50). Sevoflurane anesthesia vs. Awake state (before anesthesia) was evaluated on Sequence baroreflex sensitivity (BRS_SEQ) (p=<0.001). Sevoflurane anesthesia significantly depressed all measured indices of spontaneous baroreflex sensitivity, including sequence BRS which decreased from 15.2 to 2.7 ms/mmHg (P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: