Why the study?
Does sevoflurane compared to halothane differentially affect cardiac baroreflex activity in anesthetized children?
Population
Children undergoing anesthesia
Comparison
Sevoflurane mask induction vs Halothane mask induction
Design
RCT, randomly assigned
Follow-up
During induction and 5 minutes after intubation
Authors
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Both agents equally suppress baroreflex activity in children; challenges prior assumptions that halothane respiratory RRI fluctuations reflect intact parasympathetic function.
Does sevoflurane compared to halothane differentially affect cardiac baroreflex activity in anesthetized children?
Both halothane and sevoflurane markedly decrease cardiac baroreflex activity in children, suggesting that previously observed respiratory RRI fluctuations under halothane may reflect reflex respiratory arrhythmia rather than efficient parasympathetic baroreflex activity.
Constant et al. (2004) studied this question.
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