Key result
Middle-aged APOE ε4 carriers exhibited significantly higher baseline cerebral blood flow in the proximal anterior cerebral artery compared to non-carriers (38.5 vs 35.0 ml/100 g/min, p=0.01).
Why the study?
Vascular dysregulation has been suggested in preclinical Alzheimer's disease, but cerebral hemodynamics and their coupling with cognition in middle-aged APOE ε4 carriers required investigation.
Does APOE ε4 carriership alter cerebral hemodynamics and cognitive performance in middle-aged adults?
Population
158 participants (40-59 years old) in the PREVENT-Dementia study
Comparison
APOEε4 carriers vs non-carriers
Design
Longitudinal MRI study
Follow-up
two-year follow-up
Authors
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May reflect early cerebrovascular adaptation in APOE ε4 carriers; leaves open implications for Alzheimer's risk monitoring.
Cohort (n=158)
No
Does APOE ε4 carriership alter cerebral hemodynamics and cognitive performance in middle-aged adults?
Mean Difference: 3.88
Absolute Event Rate: 38.5% vs 35%
p-value: p=0.01
Middle-aged APOE ε4 carriers exhibit cerebral hemodynamic dysregulation, characterized by increased cerebral blood flow and decreased cerebrovascular resistance, which may represent an early compensatory mechanism prior to cognitive decline.
Dounavi et al. (2021) conducted a cohort in Preclinical Alzheimer's disease risk (n=158). APOE ε4 carriership vs. APOE ε4 non-carriers was evaluated on Baseline cerebral blood flow (CBF) in the proximal anterior cerebral artery (ACA) (β 3.88, p=0.01). Middle-aged APOE ε4 carriers exhibited significantly higher baseline cerebral blood flow in the proximal anterior cerebral artery compared to non-carriers (38.5 vs 35.0 ml/100 g/min, p=0.01).
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