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August 1, 1989The Journal of Experimental Medicine

Tumor necrosis factor identified in multiple sclerosis brain.

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Population

Frozen brain specimens from patients with multiple sclerosis and other neurologic diseases

Comparison

Immunocytochemical analysis for tumor necrosis… vs Alzheimer's disease or normal brain tissue

Design

Other

Authors

FHFlorence M. HofmanUniversity of Southern CaliforniaDHDavid R. HintonUniversity of Southern CaliforniaKJK. P. JohnsonUniversity of Maryland, Baltimore

Discussion

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Implication

Implicates TNF in MS lesion pathology; hypothesis-generating for cytokine-targeted therapies without practice change.

Structured PICO

P
Population
Frozen brain specimens from patients with multiple sclerosis (MS) and other neurologic diseases (subacute sclerosing panencephalitis, Alzheimer's disease, normal brain tissue)
I
Intervention
Immunocytochemical analysis for tumor necrosis factor (TNF)
C
Comparator
Alzheimer's disease or normal brain tissue
O
Outcome
Presence and localization of TNF+ cellssurrogate

The presence of TNF in MS lesions suggests a significant role for cytokines and the immune response in disease progression.

Cite This Study

Hofman et al. (1989) studied this question.

synapsesocial.com/papers/6a706c15fe4101aa97e02794https://doi.org/10.1084/jem.170.2.607
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.1982 · 753 citations
  2. 2Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain.1986 · 318 citations
  3. 3Analysis of B-cell antigens in normal reactive lymphoid tissue using four B-cell monoclonal antibodies1983 · 32 citations
  4. 4Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.1987 · 429 citations
  5. 5Expression of tumor necrosis factor receptors on human monocytes and internalization of receptor bound ligand.1987 · 103 citations