Key result
Rosiglitazone directly regulates transcription of adipose triglyceride lipase (ATGL), likely through a PPARgamma-mediated mechanism.
Population
Male C57Bl/6 mice and preadipocyte (3T3-L1) cells
Design
Preclinical
Authors
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Animal findings on rosiglitazone and ATGL transcription are hypothesis-generating; do not inform clinical practice.
Rosiglitazone directly regulates the transcription of adipose triglyceride lipase (ATGL) via a PPARgamma-mediated mechanism in preclinical models.
Liu et al. (2008) studied this question. Rosiglitazone was evaluated on ATGL mRNA and protein levels. Rosiglitazone directly regulates transcription of adipose triglyceride lipase (ATGL), likely through a PPARgamma-mediated mechanism.
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