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May 1, 2002DiabetesOpen Access

Insulin and Rosiglitazone Regulation of Lipolysis and Lipogenesis in Human Adipose Tissue In Vitro

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Population

Human abdominal subcutaneous fat (n=12)

Comparison

Insulin, rosiglitazone, and insulin in… vs Control

Design

Preclinical

Authors

PMPhilip G. McTernanGeneral / Preventive / LipidsAHAlison L. HarteUniversity Hospitals of Leicester NHS TrustLALeah A. AndersonSolihull Hospital

Discussion

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Implication

May link hyperinsulinemia to elevated FFAs in diabetes models; hypothesis-generating and requires human validation.

Structured PICO

P
Population
Human abdominal subcutaneous fat (n=12)
I
Intervention
Insulin, rosiglitazone (RSG), and insulin in combination with RSG
C
Comparator
Control
O
Outcome
Lipolysis and lipogenesis assessed by protein expression of hormone-sensitive lipase (HSL) and lipoprotein lipase (LPL), glycerol release, and TNF-alpha releasesurrogate

Chronic treatment of human adipocytes with insulin stimulates lipolysis and LPL protein expression, while the addition of rosiglitazone reduces the lipolytic rate and TNF-alpha secretion, potentially explaining hyperinsulinemia's coexistence with increased free fatty acids in obesity and type 2 diabetes.

Cite This Study

McTernan et al. (2002) studied this question.

synapsesocial.com/papers/6a828cd2f5f149803a21dc1ahttps://doi.org/10.2337/diabetes.51.5.1493
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship between lipoprotein lipase activity and plasma sex steroid level in obese women.1988 · 102 citations
  2. 2Rosiglitazone taken once daily provides effective glycaemic control in patients with Type 2 diabetes mellitus2000 · 117 citations
  3. 3The Role of Free Fatty Acid Metabolism in the Pathogenesis of Insulin Resistance in Obesity and Noninsulin-Dependent Diabetes Mellitus*1991 · 314 citations
  4. 4Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase.1994 · 162 citations