Key result
Patients with impaired glucose tolerance had a significantly reduced hepatic free fatty acid influx rate constant compared to control subjects (0.288 vs 0.341 min-1; P<0.02).
Why the study?
Does impaired glucose tolerance affect hepatic free fatty acid uptake compared to healthy controls?
Population
10 patients with impaired glucose tolerance (IGT) and 8 control subjects (total n=18).
Design
Case-control
Authors
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Impaired glucose tolerance was associated with reduced hepatic free fatty acid uptake; hypothesis-generating and requires prospective validation before clinical consideration.
Case-Control (n=18)
Does impaired glucose tolerance affect hepatic free fatty acid uptake compared to healthy controls?
Absolute Event Rate: 0.288% vs 0.341%
p-value: p=<0.02
Patients with impaired glucose tolerance exhibit a reduced ability of the liver to extract free fatty acids from the circulation, likely due to intrahepatic substrate competition.
Iozzo et al. (2004) conducted a case-control in Impaired glucose tolerance (n=18). Impaired glucose tolerance vs. Control subjects was evaluated on Hepatic FFA influx rate constant (LKi) (p=<0.02). Patients with impaired glucose tolerance had a significantly reduced hepatic free fatty acid influx rate constant compared to control subjects (0.288 vs 0.341 min-1; P<0.02).
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