Key result
Whole blood viscosity was significantly higher in patients with coronary slow flow phenomenon and correlated with corrected TIMI frame count at low (r=0.562) and high (r=0.611) shear rates.
Why the study?
Is whole blood viscosity associated with coronary slow flow phenomenon?
Case-Control (n=400)
Is whole blood viscosity associated with coronary slow flow phenomenon?
Whole blood viscosity is significantly associated with and an independent predictor of coronary slow flow phenomenon.
Elevated viscosity may contribute to coronary slow flow; hypothesis-generating and requires prospective validation before clinical consideration.
AIMS: We aimed to assess the relationship between coronary slow flow phenomenon (CSFP) and whole blood viscosity (WBV). MATERIALS & METHODS: Two hundred patients with CSFP and 200 subjects with normal coronary arteries as control group were enrolled. WBV was calculated from hematocrit and plasma protein concentration at low shear rate (LSR) (0.5 s(-1)) and high shear rate (HSR) (208 s(-1)) by a validated equation. RESULTS: CSFP patients had significantly higher WBV for LSR and HSR. The mean corrected TIMI frame count was highest in the highest tertile group for both shear rates. Corrected TIMI frame count revealed a significant relationship with WBV for LSR (r = 0.562) and HSR (r = 0.611). At multivariate analysis, WBV at LSR and HSR were independent predictors of CSFP. CONCLUSION: WBV seemed to have a significant and an independent predictor of CSFP.
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Çetin et al. (2015) conducted a case-control in Coronary slow flow phenomenon (n=400). Whole blood viscosity vs. Normal coronary arteries (control group) was evaluated on Presence of coronary slow flow phenomenon. Whole blood viscosity was significantly higher in patients with coronary slow flow phenomenon and correlated with corrected TIMI frame count at low (r=0.562) and high (r=0.611) shear rates.
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