Key result
A computational model incorporating lateral mechanical equilibrium and the inverse relationship between sarcomere length and lattice spacing successfully reproduced spontaneous oscillatory contraction phenomena in myofibrils.
Why the study?
Spontaneous oscillatory contraction phenomena cannot be explained simply by Ca2+ regulation or longitudinal mechanical equilibrium among sarcomeres in a myofibril.
This computational model demonstrates that lateral mechanical equilibrium and the inverse relationship between sarcomere length and lattice spacing are crucial for mechanical communication between motor proteins during spontaneous oscillatory contraction.
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Supports myofibril modeling; leaves open clinical translation to cardiac disease.
Washio et al. (2019) studied Muscle contraction mechanics. Computational modeling of myofibril passive elastic properties was evaluated. A computational model incorporating lateral mechanical equilibrium and the inverse relationship between sarcomere length and lattice spacing successfully reproduced spontaneous oscillatory contraction phenomena in myofibrils.
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