October 1, 1993Circulation Research
Spontaneous sarcomeric oscillations at intermediate activation levels in single isolated cardiac myofibrils.
Key result
In single isolated cardiac myofibrils without sarcoplasmic reticulum, partial activation initiated undamped propagated sarcomeric oscillations that persisted up to 1 hour.
Population
Single isolated cardiac myofibrils treated with Triton X-100 to remove sarcoplasmic reticulum (SR)
Design
Preclinical
Authors
Discussion
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Implication
Does not inform clinical arrhythmia management; leaves open myofibrillar contributions to cardiac auto-oscillations.
Structured PICO
P
Population
Single isolated cardiac myofibrils treated with Triton X-100 to remove sarcoplasmic reticulum (SR)
I
Intervention
Partial activation and isometric holding
O
Outcome
Characteristics of spontaneous sarcomeric oscillations (period, amplitude, propagation velocity)
Spontaneous sarcomeric oscillations can occur in cardiac myofibrils independent of sarcoplasmic reticulum calcium release, suggesting a mechanism involving length-dependent myofibrillar Ca2+ sensitivity.
Cite This Study
Linke et al. (1993) studied Isolated cardiac myofibrils. Partial activation after Triton X-100 treatment was evaluated on Spontaneous sarcomeric oscillations. In single isolated cardiac myofibrils without sarcoplasmic reticulum, partial activation initiated undamped propagated sarcomeric oscillations that persisted up to 1 hour.