Key result
In isolated hamster hearts, calcium overload-induced spontaneous myocardial oscillation impairs systolic and diastolic function, with effects associated with the spatial extent and strength of the oscillation.
Population
Isolated hamster hearts
Comparison
Calcium overload with or without ryanodine vs Lower calcium concentrations (1 mmol/l [Ca2+]o)
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether oscillations contribute to human ventricular dysfunction.
In isolated hamster hearts, calcium overload-induced spontaneous myocardial oscillation impairs both systolic and diastolic ventricular function.
SHINOZAKI et al. (1996) studied Calcium overload. Calcium overload vs. Baseline (1 mmol/l [Ca2+]o) was evaluated on Ventricular performance (developed pressure, maximum rate of pressure rise) and myocardial oscillation strength/extent. In isolated hamster hearts, calcium overload-induced spontaneous myocardial oscillation impairs systolic and diastolic function, with effects associated with the spatial extent and strength of the oscillation.
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