Key result
In isolated hamster hearts, calcium overload induced spontaneous myocardial oscillation that impaired systolic and diastolic function, an effect that was eliminated by ryanodine.
Population
Isolated hamster hearts
Comparison
Calcium overload and ryanodine vs Lower calcium concentrations or absence of…
Design
Preclinical
Authors
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Calcium oscillations may impair ventricular function; leaves open whether ryanodine-sensitive pathways offer therapeutic targets in human cardiomyopathy.
Spontaneous myocardial oscillation induced by calcium overload impairs systolic and diastolic function in intact ventricles, associated with the spatial extent and strength of the oscillation.
Shinozaki et al. (1996) studied Calcium overload. Calcium concentration and ryanodine was evaluated on Developed pressure, maximum rate of pressure rise, and capillary oscillation. In isolated hamster hearts, calcium overload induced spontaneous myocardial oscillation that impaired systolic and diastolic function, an effect that was eliminated by ryanodine.
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