Key result
Abrupt changes in load or length induced an oscillatory response in cat and frog heart muscle preparations, indicating that length influences the level of activation during contraction.
Population
Preparations of cat and frog heart muscle
Design
Preclinical
Authors
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Should not change clinical practice; hypothesis-generating for length-dependent activation in intact myocardium.
The study demonstrates that length influences the level of activation during contraction of heart muscle, likely mediated by Ca2+ or Sr2+ rather than intrinsic myofilament interaction.
Henderson et al. (1976) studied this question. Abrupt changes in load or length was evaluated on Transient response to abrupt changes in load or length (oscillatory response). Abrupt changes in load or length induced an oscillatory response in cat and frog heart muscle preparations, indicating that length influences the level of activation during contraction.
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