Key result
Substitution of strontium for calcium in mammalian heart muscle delayed the onset of maximum unloaded active velocity to 30-35% of the time to peak force, compared to 16% in calcium solutions.
Population
Mammalian heart muscle
Comparison
Strontium-containing solutions vs Calcium-containing solutions
Design
Preclinical
Authors
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Strontium substitution effects on activation timing warrant no clinical extrapolation; extends basic force-velocity insights in mammalian muscle but leaves human relevance open.
The substitution of strontium for calcium delays the onset of mechanical activation in mammalian heart muscle, highlighting a close relationship between the force-velocity-length time course and the degree of activation.
Brutsaert et al. (1974) studied Mammalian heart muscle mechanics. Strontium (Sr)-containing solutions vs. Calcium (Ca)-containing solutions was evaluated on Onset of the force-velocity-length relationship (unloaded active muscle shortening velocity). Substitution of strontium for calcium in mammalian heart muscle delayed the onset of maximum unloaded active velocity to 30-35% of the time to peak force, compared to 16% in calcium solutions.
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