Key result
A novel multiscale heart simulation method integrating microscopic stochastic sarcomere kinetics to macroscopic heartbeat was introduced and its robustness and accuracy were verified.
The introduced multiscale heart simulation method successfully integrates microscopic sarcomere kinetics with macroscopic heartbeat, providing a robust tool for physiological studies.
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May advance in silico cardiac research; leaves open clinical translation pending prospective validation.
Washio et al. (2013) studied this question. Multiscale heart simulation method was evaluated. A novel multiscale heart simulation method integrating microscopic stochastic sarcomere kinetics to macroscopic heartbeat was introduced and its robustness and accuracy were verified.
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