Key result
Serum concentrations of ANGPTL3 and ANGPTL4 were negatively correlated with estimated glomerular filtration rate (r = -0.32 and rS = -0.31, respectively, p < 0.001) in patients with rheumatoid arthritis.
Why the study?
The study was conducted to assess the relationship between serum concentrations of ANGPTL 3 and 4 and the development of renal dysfunction in patients with rheumatoid arthritis with metabolic changes.
Cross-Sectional (n=158)
No
Effect estimate: r = -0.32 (ANGPTL3) and rS = -0.31 (ANGPTL4)
p-value: p=<0.001
In patients with rheumatoid arthritis, renal dysfunction and metabolic syndrome are directly associated with increased serum concentrations of ANGPTL 4, suggesting it as a key link between these conditions.
The article is devoted to the assessment of the relationship between the serum concentrations of angiopoietin-like proteins of types 3 and 4 (ANGPTL 3 and 4) and the development of renal dysfunction in patients with rheumatoid arthritis (RA) with metabolic changes. We examined 158 patients with RA (91,8 % - women and 8,2 % - men) aged 21 to 80 years old with the average duration of diseases - 9 [4-15] years. Negative correlations of average strength between the indices of the estimated glomerular filtration rate (eGFR) according to the 2009 CKD-EPI formula and the level of ANGPTL 3 (r = -0,32, p < 0,001) and ANGPTL 4 (rS = -0,31, p < 0,001) were revealed. It was found that renal dysfunction and the presence of metabolic syndrome (R2 = 0,33) are the two factors which have a direct effect on the ANGPTL 4 concentration in RA patients' serum. ANGPTL type 4 should be considered as a key factor linking the development of renal dysfunction and metabolic changes caused by rheumatoid inflammation.
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Александров et al. (2020) conducted a cross-sectional in Rheumatoid arthritis (n=158). Serum concentrations of ANGPTL3 and ANGPTL4 vs. Higher vs lower eGFR and presence vs absence of metabolic syndrome was evaluated on Correlation between estimated glomerular filtration rate (eGFR) and serum levels of ANGPTL3 and ANGPTL4 (r = -0.32 (ANGPTL3) and rS = -0.31 (ANGPTL4), p=<0.001). Serum concentrations of ANGPTL3 and ANGPTL4 were negatively correlated with estimated glomerular filtration rate (r = -0.32 and rS = -0.31, respectively, p < 0.001) in patients with rheumatoid arthritis.
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