What question did this study set out to answer?

To assess the long-term effects of a multifactorial intervention on mortality and cardiovascular disease outcomes in men.

September 1, 1996Circulation

Mortality After 16 Years for Participants Randomized to the Multiple Risk Factor Intervention Trial

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Why the study?

Does a multifactorial cardiovascular risk intervention reduce long-term mortality in high-risk men?

Population

12,866 high-risk men

Comparison

Special intervention consisting of dietary… vs Usual care

Design

RCT, Randomized to special intervention (SI) or usual care (UC)

Follow-up

16 years

Discussion

Member takes

Implication

Supports sustained AMI mortality reduction from multifactorial intervention in high-risk men; extends 7-year RCT findings to 16-year follow-up.

Key Points

To assess the long-term effects of a multifactorial intervention on mortality and cardiovascular disease outcomes in men.
Follow-up of 12,866 men randomized to special intervention or usual care groups after 16 years.
Intervention included dietary recommendations, antihypertensive drugs, and smoking cessation counseling.
Mortality rates from coronary heart disease, cardiovascular disease, and total mortality were compared between groups.
370 deaths from coronary heart disease in the special intervention group vs. 417 in usual care, an 11.4% lower mortality rate (95% CI, -23% to 1.9%).
Total mortality: 991 deaths in special intervention vs. 1050 in usual care, relative difference of -5.7% (95% CI, -13% to 2.8%).
For acute myocardial infarction, the relative difference was -20.4% (95% CI, -34.4% to -3.4%).

Structured PICO

Does a multifactorial cardiovascular risk intervention reduce long-term mortality in high-risk men?

Population

12,866 high-risk men

Intervention

Special intervention (SI) consisting of dietary recommendations to lower blood cholesterol, antihypertensive drugs to lower blood pressure, and counseling for cigarette smoking cessation during a 7-year active-intervention phase

Comparator

Usual care (referred to usual source of medical care)

Outcome

Coronary heart disease (CHD) mortality, cardiovascular death (CVD), and total mortality at 16 yearshard clinical

A 7-year multifactorial cardiovascular risk intervention program provides long-term mortality benefits, particularly in reducing acute myocardial infarction deaths, at 16 years follow-up.

Cite This Study

A 1996 study studied this question.

synapsesocial.com/papers/6a70704de36a167817e237cd https://doi.org/10.1161/01.cir.94.5.946

Topics

Hypertension management

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Implication

Supports sustained AMI mortality reduction from multifactorial intervention in high-risk men; extends 7-year RCT findings to 16-year follow-up.

Mortality After 16 Years for Participants Randomized to the Multiple Risk Factor Intervention Trial

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Mortality After 16 Years for Participants Randomized to the Multiple Risk Factor Intervention Trial

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider