Key result
Amiodarone plasma concentrations between 0.5 and 2.5 mg/L appear to be the most effective for treating arrhythmias, though the correlation between plasma levels and clinical efficacy remains highly variable.
Why the study?
Does therapeutic drug monitoring of amiodarone and its metabolite correlate with clinical efficacy in patients with arrhythmias?
Does therapeutic drug monitoring of amiodarone and its metabolite correlate with clinical efficacy in patients with arrhythmias?
Therapeutic drug monitoring of amiodarone can help determine optimal individual effective concentrations, generally between 0.5 and 2.5 mg/L, given its complex pharmacokinetics and variable clinical response.
Cautions against routine plasma monitoring to guide amiodarone dosing; leaves open need for prospective validation of therapeutic ranges.
Amiodarone is the most effective agent in the therapy of arrhythmias. However, the clinical effect of acute and chronic treatment is unclear and there are differences irrespective of comparable plasma/myocardial amiodarone and its metabolite desethylamiodarone concentations as well. Its unusual pharmacokinetics results in interindividual variation in plasma levels. The association between amiodarone and desethylamiodarone plasma levels and clinical efficacy is difficult to evaluate. This review was carried out to assess whether there is any objective correlation between amiodarone and desethylamiodarone plasma levels and the clinical effect. We summarized the results of relevant studies and clarified the relationship between plasma levels and effect vis á vis the pharmacokinetics and pharmacogenetics of this drug. Certain correlation was seen with oral amiodarone therapy, in others, plasma amiodarone levels were unrelated to therapeutic response and showed no correlation with changes in electrocardiogram or electrophysiological parametres. Several studies show that plasma concentration ranging between 0.5 and 2.5 mg/L appears to be the most effective, others demonstrate no difference between responders and non-responders. One way of interpreting plasma levels is to establish an individual patient´s effective concentration. Therapeutic drug monitoring can contribute to determining optimal concentration.
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Vyskocilova et al. (2017) conducted a review in Arrhythmias. Amiodarone was evaluated. Amiodarone plasma concentrations between 0.5 and 2.5 mg/L appear to be the most effective for treating arrhythmias, though the correlation between plasma levels and clinical efficacy remains highly variable.
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